https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Investigating causal mechanisms in randomised controlled trials https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45140 Wed 26 Oct 2022 13:33:35 AEDT ]]> Synergistic effects of hip/knee osteoarthritis and comorbidities on mobility and self-care limitations among older adults: cross-sectional analysis of the Oxford Pain, Activity and Lifestyle Study https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45843 Wed 09 Nov 2022 10:03:16 AEDT ]]> An overview of systematic reviews found suboptimal reporting and methodological limitations of mediation studies investigating causal mechanisms https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37043 Tue 08 Aug 2023 10:05:37 AEST ]]> A guideline for reporting mediation analyses of randomized trials and observational studies: the AGReMA statement https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49453 Thu 18 May 2023 11:23:00 AEST ]]> The findings of a surgical hip fracture trial were generalizable to the UK national hip fracture database https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:43444 n = 958) demonstrated that a modular hemiarthroplasty implant conferred no additional benefit over the traditional monoblock implant for quality of life and length of hospital stay. We compared and weighted the trial sample against two target populations: WHiTE-cohort (n = 2,457) and UK-National Hip Fracture Database (NHFD, n = 190,894), and re-estimate expected treatment effects for the target populations. Results: Despite differences in baseline characteristics of the trial sample and target populations, the re-estimated treatment effects were comparable. For quality of life, the differences between the trial estimate and WHiTE-cohort and NHFD estimates were 0.01 points on the EuroQol (EQ5D). For length of stay, the difference between the trial estimate and WHiTE-cohort was 0.50 days; and the difference between the trial estimate and NHFD estimate was −0.47 days. Conclusion: This generalizability analysis of the WHiTE-3 trial found that the inferences from the trial can be generalized to a wider population of individuals in the UK NHFD and the WHiTE-cohort who met the inclusion criteria for WHiTE-3.]]> Mon 19 Sep 2022 14:37:34 AEST ]]> Development of A Guideline for Reporting Mediation Analyses (AGReMA) https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54101 Mon 05 Feb 2024 09:35:39 AEDT ]]>